Clay made his professional debut on October 29, 1960, winning a six-round decision over Tunney Hunsaker. From then until the end of 1963, Clay amassed a record of 19–0 with 15 wins by knockout. He defeated boxers including Tony Esperti, Jim Robinson, Donnie Fleeman, Alonzo Johnson, George Logan, Willi Besmanoff, LaMar Clark, Doug Jones and Henry Cooper. Clay also beat his former trainer and veteran boxer Archie Moore in a 1962 match.